Neuro-signal peptide
Argireline
INCI: Acetyl Hexapeptide-8·Studied at 5–10%·Limited evidence
A peptide marketed as a topical option studied for the appearance of expression lines, sometimes called a "topical alternative" in marketing copy.
Studied for
- ·The appearance of expression lines
How it’s thought to work
Studied for association with reduced appearance of expression-line depth in cosmetic research; topical penetration is debated.
Questions
- Does Argireline really work?
- Evidence is limited and mixed. Some studies report improvement in the appearance of expression lines, and independent reviewers note questions about how well it penetrates and whether it is dosed high enough to matter.